A. Maruthasalam1, K. Vasantha1*, R.C. Rency2 and S. Ashok Kumar2
1PG and Research Department of Botany, Govt. Arts College (Autonomous), Coimbatore - 641 018, Tamil Nadu, India
2Research and Development Centre, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India
*Email: [email protected]
Article Info |
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Abstract |
Received: 10-05-2019, |
Medicinal plants have been used for the cure of various diseases all over the world before the invention of clinical drugs. The use of medicinal plants for treatment and control of diseases has been gaining importance worldwide particularly in developing countries. Cancer is the most dreadful and one of the leading causes of death all around the world. Colorectal cancers are the third most common cancer in both men and women. A number of chemical compounds and their derivatives reported from a vast variety of medicinal plants are accepted as alternative medicine for cancer. With this back ground, the present study is focused on evaluating the cytotoxic effects of ethanolic extracts of Anaphalis neelgherryana leaves and barks against HCT -15 (Human Colorectal Carcinoma) cell lines using MTT assay. Ethanolic extracts of bark showed the strongest cytotoxic activity against the cell lines. The results revealed that the cytotoxic potential of A. neelgherryana increased when the concentration of plant extracts increases. The present study may provide the beacon for further purification to obtain a potentially active and pure compound from A. neelgherryana for effective anticancer drugs. |
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How to cite this article
A Maruthasalam, K Vasantha, RC Rency and S Ashok Kumar, 2019. In vitro Cytotoxicity Studies of Anaphalis neelgherryana DC. Leaves and Barks against Human Colorectal Cancer Cell Lines (HCT 15). Bioscience Discovery, 10(3):112-118.
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